A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis

作者：Chen Wang, Jian-Feng Chang, Hongli Yan, Da-Liang Wang, Yan Liu, Yuanya Jing, Meng Zhang, Yu‐Long Men, Dongdong Lu, Xiaomei Yang, Su Chen, Fang-Lin Sun · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.5011 · 被引用次数：19 · 研究领域：Ubiquitin and proteasome pathways、Genomics and Chromatin Dynamics、Protein Degradation and Inhibitors

// Chen Wang 1, 2, 3, * , Jian-Feng Chang 1, 2, * , Hongli Yan 4, * , Da-Liang Wang 5 , Yan Liu 5 , Yuanya Jing 2 , Meng Zhang 2 , Yu-Long Men 2 , Dongdong Lu 2 , Xiao-Mei Yang 2 , Su Chen 1, 2, 6 , Fang-Lin Sun 1, 2 1 Research Center for Translational Medicine at East Hospital, Tongji University, Shanghai, 200120/200092, China 2 School of Life Sciences and Technology, Tongji University, Shanghai, 200120/200092, China 3 UN School of Environmental Sciences and Technology, Tongji University, Shanghai, 200120/200092, China 4 Department of Laboratory Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, China 5 Institute of Epigenetics and Cancer Research, School of Medicine, Tsinghua University, Beijing, 100084, China 6 Department of Science and Education, People’s Hospital of Zunhua, Tangshan, Hebei, 064200, China * These authors have contributed equally to this work Correspondence to: Fang-Lin Sun, e-mail: sfl@tongji.edu.cn Su Chen, e-mail: chensu@tongji.edu.cn Xiao-Mei Yang, e-mail: yxm411@tongji.edu.cn Keywords: RAD6, MDM2, ASF1A, protein degradation, tumorigenesis Received: March 06, 2015      Accepted: August 12, 2015      Published: August 22, 2015 ABSTRACT Chromatin is a highly organized and dynamic structure in eukaryotic cells. The change of chromatin structure is essential in many cellular processes, such as gene transcription, DNA damage repair and others. Anti-silencing function...