GENETIC ANALYSIS OF THE ANTENNAPEDIA GENE COMPLEX (ANT-C) AND ADJACENT CHROMOSOMAL REGIONS OF DROSOPHILA MELANOGASTER. I. POLYTENE CHROMOSOME SEGMENTS 84B-D

作者：R A Lewis, Thomas C. Kaufman, Robin E. Denell, P. Tallerico · 发表于：Genetics · 年份：1980 · DOI：10.1093/genetics/95.2.367 · 被引用次数：166 · 研究领域：Developmental Biology and Gene Regulation、Chromosomal and Genetic Variations、Genomics and Chromatin Dynamics

A deficiency spanning section 84B-D of the proximal right arm of chromosome 3 of Drosophila melanogaster has been utilized as a screen for mutations that aid in the genetic dissection of this developmentally interesting region.-Ninety-two mutations have been recovered, of which 12 have been localized by deficiency and complementation mapping to the 84B1,2 doublet, the site of the Antennapedia complex (ANT-C). This has permitted a more precise description of the genetic organization of this complex locus.-A collection of 31 mutations that reside in 84C1-D2 displays an intricate circular complementation pattern, characterized by two clusters of mutations that exhibit semi-lethality, negative complementation and temperature sensitivity. Mutations affecting seven additional functional groups within the 84B-D region were also recovered.