microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer

作者：Dong-liang Chen, Dong-sheng Zhang, Yun-Xin Lu, Le-Zong Chen, Zhao-Lei Zeng, Ming-Ming He, Feng-Hua Wang, Yuhong Li, Hui-Zhong Zhang, Hélène Pelicano, Wei Zhang, Rui‐Hua Xu · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.3451 · 被引用次数：75 · 研究领域：MicroRNA in disease regulation、Cancer-related molecular mechanisms research、Circular RNAs in diseases

// Dong-liang Chen 1, 2 * , Dong-sheng Zhang 1, 2 * , Yun-xin Lu 1, 2 , Le-zong Chen 1, 2 , Zhao-lei Zeng 1, 3 , Ming-ming He 1, 2 , Feng-hua Wang 1, 2 , Yu-hong Li 1, 2 , Hui-zhong Zhang 1, 4 , Helene Pelicano 5 , Wei Zhang 6 , Rui-hua Xu 1, 2 1 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China 2 Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China 3 Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, China 4 Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China 5 Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA 6 Department of Pathology, Unit 85, Center for RNAi and Non-Coding RNA, University of Texas MD Anderson Cancer Center, Houston, TX, USA * These authors have contributed equally to this work Correspondence to: Rui-hua Xu, e-mail: xurh@sysucc.org.cn Keywords: microRNA, microRNA-217, EZH2, gastric cancer, metastasis Received: January 9, 2015      Accepted: February 25, 2015      Published: March 26, 2015 ABSTRACT microRNA-217 (miR-217) is frequently dysregulated in cancer. Here, we report that miR-217 levels were lower in tumor tissue compared with the adjacent normal tissue. Low levels of miR-217 were associated with aggressive tumor phenotypes and poor overal...