The acute hepatotoxicity of tacrine explained by1H NMR based metabolomic profiling

作者：Yanhong Lou, Junsong Wang, Ge Dong, Pingping Guo, Dandan Wei, Sai‐Sai Xie, Ming‐Hua Yang, Lingyi Kong · 发表于：Toxicology Research · 年份：2015 · DOI：10.1039/c5tx00096c · 被引用次数：28 · 研究领域：Metabolomics and Mass Spectrometry Studies、Analytical Chemistry and Chromatography、Drug-Induced Hepatotoxicity and Protection

NMR based metabolomics approach was applied to study the mechanism of tacrine-induced acute hepatotoxicity and had found significant disturbances.