Analysis of airspace and interstitial mononuclear cell populations in human diffuse interstitial lung disease.

作者：G S Davis, Arnold R. Brody, J E Craighead · 发表于：PubMed · 年份：1978 · DOI：10.1164/arrd.1978.118.1.7 · 被引用次数：117 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Medical Imaging and Pathology Studies

Increased numbers of mononuclear cells are found in the pulmonary interstitium and airspaces in chronic fibrotic lung diseases. Light and electron microscopic study of lung biopsy specimens from 28 cases of diffuse interstitial lung disease and of 7 normal lung tissue specimens permitted semi-quantitative analysis of the numbers and types of mononuclear cells found in the airspaces and interstitium. Pulmonary alveolar macrophages and lymphocytes were the predominant cell types free in the airspaces in normal lung tissue and in specimens from patients with chronic fibrotic lung diseases. Increased percentages of lymphocytes were found in the airspaces of patients with diffuse interstitial lung diseases. An approximately ten-fold or greater increase in the percentage of airspace lymphocytes was found in the lungs of patients with hypersensitivity pneumonitis, connective tissue diseases, and lymphoid interstitial pneumonitis, whereas an approximately 4-fold or smaller increase was found in idiopathic pulmona...