Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis?

作者：Qingchun Huang, Maojie Wang, Xiumin Chen, Wanlin Yu, Yong‐Liang Chu, Xiaohong He, Run-Yue Huang · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.6200 · 被引用次数：101 · 研究领域：Pharmacological Effects of Natural Compounds、Rheumatoid Arthritis Research and Therapies、Ginseng Biological Effects and Applications

// Qing-Chun Huang 1 , Mao-Jie Wang 2 , Xiu-Min Chen 1 , Wan-Lin Yu 2 , Yong-Liang Chu 1 , Xiao-Hong He 1 and Run-Yue Huang 1 1 Department of Rheumatology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China 2 Central Laboratory, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China Correspondence to: Run-Yue Huang, email: // Keywords : licorice, glycyrrhizin, glycyrrhetinic acid, rheumatoid arthritis, the COX-2/TxA2 pathway Received : August 03, 2015 Accepted : October 09, 2015 Published : October 20, 2015 Abstract OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway. METHODS: The extensive literature from inception to July 2015 was searched in PubMed central, and relevant reports were identified according to the purpose of this study. RESULTS: The active components of licorice GL and GA exert the potential anti-inflammatory effects through, at least in part, suppressing COX-2 and its downstream product TxA2. Additionally, the COX-2/TxA2 pathway, an auto-regulatory feedback loop, has been recently found to be a crucial mechanism underlying the pathogenesis of RA. However, TxA2 is neither the pharmacological ...