RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth

作者：Qin Yu, Wangbing Chen, Yao Xiao, Wendan Yu, Xin Cai, Meng Dai, Tingting Xu, Wenlin Huang, Wei Guo, Wuguo Deng, Taihua Wu · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.4825 · 被引用次数：23 · 研究领域：Telomeres, Telomerase, and Senescence、Genomics and Chromatin Dynamics、Advanced biosensing and bioanalysis techniques

// Yu Qin 1, * , Wangbing Chen 2, 3, * , Yao Xiao 1, * , Wendan Yu 1 , Xin Cai 1 , Meng Dai 1 , Tingting Xu 1 , Wenlin Huang 2, 4 , Wei Guo 1 , Wuguo Deng 2, 4 , Taihua Wu 1 1 The First Affiliated Hospital and Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 2 Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China 3 Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4 State Key Laboratory of Targeted Drug for Tumors of Guangdong Province, Guangzhou Double Bioproduct Inc., Guangzhou, China * These authors have contributed equally to this work Correspondence to: Wuguo Deng, e-mail: dengwg@sysucc.org.cn Wei Guo, e-mail: wei1015@msn.com Taihua Wu, e-mail: wutaihua@sina.com Keywords: RFPL3, CBP, hTERT, lung cancer Received: March 21, 2015      Accepted: July 30, 2015      Published: August 11, 2015 ABSTRACT hTERT is the key component of telomerase and its overactivation contributes to maintaining telomere length and cell immortalization. Previously, we identified RFPL3 as a new transcription activator of hTERT in lung cancers. However, the exact mechanism of RFPL3 in mediating hTERT activation and its associated signal regulatory network remain unclear. In this study, we found that RFPL3 colocalized and interacted directly with CBP in the nucleus ...