MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1

作者：Zhuoyuan Lin, Yaqiang Huang, Yanqiong Zhang, Zhaodong Han, Huichan He, Xiaohui Ling, Xin Fu, Qi-Shan Dai, Chao Cai, Jiahong Chen, Yuxiang Liang, Funeng Jiang, Weide Zhong, Fen Wang, Chin‐Lee Wu · 发表于：International Journal of Cancer · 年份：2013 · DOI：10.1002/ijc.28707 · 被引用次数：110 · 研究领域：MicroRNA in disease regulation、Cancer-related molecular mechanisms research、Circular RNAs in diseases

Our previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. However, the underlying mechanisms by which miR-224 is involved in PCa remain unclear. In this study, we identified TRIB1 as a target gene of miR-224. Forced expression of miR-224 suppressed PCa cell proliferation, invasion and migration, and promoted cell apoptosis by downregulating TRIB1. Moreover, the expression level of miR-224 in PCa tissues was negatively correlated with that of TRIB1. miR-224 downregulation was frequently found in PCa tissues with metastasis, higher PSA level and clinical stage, whereas TRIB1 upregulation was significantly associated with metastasis. Both miR-224 downregulation and TRIB1 upregulation were significantly associated with poor biochemical recurrence-free survival of patients with PCa. In conclusion, these findings reveal that the aberrant expression of miR-224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis.