Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

作者：Marc J. van de Vijver, R van de Bersselaar, Peter Devilee, Cornelisse Cj, Johannes L. Peterse, Roel Nusse · 发表于：Molecular and Cellular Biology · 年份：1987 · DOI：10.1128/mcb.7.5.2019 · 被引用次数：331 · 研究领域：HER2/EGFR in Cancer Research、Neuroblastoma Research and Treatments、Monoclonal and Polyclonal Antibodies Research

We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous.