Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

作者：Michele Simbolo, Matteo Fassan, Andrea Ruzzenente, Andrea Mafficini, Laura DeLong Wood, Vincenzo Corbo, Davide Melisi, Giuseppe Malleo, Caterina Vicentini, Giorgio Malpeli, Davide Antonello, Nicola Sperandio, Paola Capelli, Anna Tomezzoli, Calogero Iacono, Rita Teresa Lawlor, Claudio Bassi, Ralph H. Hruban, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud, Aldo Scarpa · 发表于：Oncotarget · 年份：2014 · DOI：10.18632/oncotarget.1943 · 被引用次数：212 · 研究领域：Cholangiocarcinoma and Gallbladder Cancer Studies、Genetic factors in colorectal cancer、RNA modifications and cancer

// Michele Simbolo 1,2,* , Matteo Fassan 1,2,* , Andrea Ruzzenente 3,* , Andrea Mafficini 1 , Laura D. Wood 4 , Vincenzo Corbo 1 , Davide Melisi 5 , Giuseppe Malleo 6 , Caterina Vicentini 1 , Giorgio Malpeli 1,3,6 , Davide Antonello 1,3,6 , Nicola Sperandio 1 , Paola Capelli 2 , Anna Tomezzoli 2 , Calogero Iacono 3 , Rita T. Lawlor 1,2 , Claudio Bassi 6 , Ralph H. Hruban 4 , Alfredo Guglielmi 3 , Giampaolo Tortora 5 , Filippo de Braud 7 , Aldo Scarpa 1,2 1 ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy 2 Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy 3 Department of Surgery, General Surgery A, University of Verona, Verona, Italy 4 Department of Pathology, Johns Hopkins University and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA 5 Department of Medical Oncology, University and Hospital Trust of Verona, Verona, Italy 6 Department of Surgery, General Surgery B, University of Verona, Verona, Italy 7 Medical Oncology Unit 1, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy * shared first authorship Correspondence: Aldo Scarpa, email: // Keywords : cholangiocarcinoma; next-generation sequencing; molecular subclassification; target therapy; multigene mutational panels Received : April 2, 2014 Accepted : April 30, 2014 Published : May 1, 2014 Abstract One-hundred-fifty-three biliary cancers, including 70 intrahepatic cholangioca...