Minocycline for acne vulgaris: efficacy and safety

作者：Sarah Garner, E. Anne Eady, Cathy Bennett, John Newton, Karen Thomas, C Popescu · 发表于：Cochrane Database of Systematic Reviews · 年份：2012 · DOI：10.1002/14651858.cd002086.pub2 · 被引用次数：215 · 研究领域：Acne and Rosacea Treatments and Effects、Dermatologic Treatments and Research、melanin and skin pigmentation

BACKGROUND: Minocycline is an oral antibiotic used for acne vulgaris. Its use has lessened due to safety concerns (including potentially irreversible pigmentation), a relatively high cost, and no evidence of any greater benefit than other acne treatments. A modified-release version of minocycline is being promoted as having fewer side-effects. OBJECTIVES: To assess new evidence on the effects of minocycline for acne vulgaris. SEARCH METHODS: Searches were updated in the following databases to November 2011: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, MEDLINE (from 1946), EMBASE (from 1974), and LILACS (from 1982). We also searched trials registers and checked reference lists for further references to relevant randomised controlled trials (RCTs).The Cochrane Skin Group's Trials Search Co-ordinator undertook searches exploring minocycline's adverse effects in EMBASE and MEDLINE in February 2012. SELECTION CRITERIA: We selected randomised controlled trials (RCTs) comparing minocycline, at any dose, to an active or a placebo control, in participants with inflammatory acne vulgaris. For adverse effects, we selected additional studies that reported the number of adverse effects and the number of participants treated. DATA COLLECTION AND ANALYSIS: Outcome measures used in the trials included lesion counts, acne grades/severity scores, doctors' and participants' global assessments, adverse effects, and dropout rates. Two authors independently assess...