Elective colon surgery: clindamycin versus metronidazole prophylaxis.

作者：Gahhos Fn, Richards Gk, Hinchey Ej, Prentis Jj · 发表于：PubMed · 年份：1982 · 被引用次数：6 · 研究领域：Surgical site infection prevention、Intestinal Malrotation and Obstruction Disorders、Colorectal Cancer Surgical Treatments

Orally administered clindamycin-neomycin as a prophylactic antibiotic in patients scheduled to undergo colon surgery was compared to orally administered metronidazole-neomycin. Clindamycin levels of the colon contents and the mucosa were 8 to 10 times higher than the serum levels. Three of the 43 patients who received metronidazole had wound infection whereas none of the 38 patients who received clindamycin did. Clindamycin may help to prevent staphylococcal infection, a known problem associated with metronidazole use. It may also play a role in preventing infection at the anastomosis in patients who undergo colon resection.