Preparation of 6‐Difluoromethylphosphonated Phenanthridines by Visible‐Light‐Driven Radical Cyclization of 2‐Isocyanobiphenyls

作者：Shuang Wang, Wen‐Liang Jia, Lin Wang, Qiang Liu · 发表于：European Journal of Organic Chemistry · 年份：2015 · DOI：10.1002/ejoc.201500988 · 被引用次数：47 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques

Abstract A protocol to obtain a variety of 6‐difluoromethylenephosphonated phenanthridines through a radical cyclization process was explored. These reactions, performed with the use of diethyl bromodifluoromethylphosphonate as a radical resource and 2‐isocyanobiphenyls as radical acceptors, were smoothly triggered by visible‐light photocatalysis. Electron‐withdrawing and electron‐donating groups were well tolerated, and the target molecules were obtained in excellent to moderate yields.