Trichosporon beigelii, an emerging pathogen resistant to amphotericin B

作者：Thomas J. Walsh, GREGORY P. MELCHER, Michael G. Rinaldi, Julius Lecciones, Deanna A. McGough, Paul M. Kelly, Jonelle K. Lee, Diana P. Callender, Marc Rubin, P A Pizzo · 发表于：Journal of Clinical Microbiology · 年份：1990 · DOI：10.1128/jcm.28.7.1616-1622.1990 · 被引用次数：312 · 研究领域：Antifungal resistance and susceptibility、Plant Pathogens and Fungal Diseases、Fungal Infections and Studies

Trichosporon beigelii caused fatal disseminated infections that were resistant to amphotericin B in two granulocytopenic patients. In vitro susceptibility studies demonstrated that both index strains of T. beigelii were inhibited but not killed by amphotericin B at achievable concentrations in serum. The minimum lethal concentration for both isolates was greater than or equal to 18 micrograms/ml. Five of seven other isolates were found to have a similar pattern of amphotericin B resistance. The fact that the minimum lethal concentration of T. beigelii was many times greater than its MIC was consistent with a resistance pattern of tolerance. We concluded that T. beigelii may be resistant in vitro to amphotericin B and that this in vitro resistance was correlated with refractory, disseminated trichosporonosis in granulocytopenic patients. T. beigelii should be included in the expanding list of amphotericin B-resistant fungi.