Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation

作者：Cecilia Cheng‐Mayer, Margarita Quiroga, James W. Tung, DINO DINA, J A Levy · 发表于：Journal of Virology · 年份：1990 · DOI：10.1128/jvi.64.9.4390-4398.1990 · 被引用次数：253 · 研究领域：HIV Research and Treatment、Immune Cell Function and Interaction、HIV/AIDS drug development and treatment

The genome of the human immunodeficiency virus type 1 (HIV-1) is highly heterogeneous. Some of this genomic variability is reflected in the biologic and serologic differences observed among various strains of HIV-1. To map the viral determinants that correlate with pathogenicity of the virus, recombinant viruses were generated between biologically active molecular clones of HIV-1 strains that show differences in T-cell or macrophage tropism, cytopathogenicity, CD4 antigen modulation, and susceptibility to serum neutralization. The results of these studies indicate that the envelope region contains the major determinants of these viral features. Further studies with sequence exchanges within this region should help identify specific domains that contribute to HIV pathogenesis.