MOF nanoparticles coated by lipid bilayers and their uptake by cancer cells

作者：Stefan Wuttke, Simone Braig, Tobias Preiß, Andreas Zimpel, Johannes Sicklinger, Claudia Bellomo, Joachim Oskar Rädler, Angelika M. Vollmar, Thomas Bein · 发表于：Chemical Communications · 年份：2015 · DOI：10.1039/c5cc06767g · 被引用次数：221 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics

We report the synthesis of MOF@lipid nanoparticles as a versatile and powerful novel class of nanocarriers based on metal-organic frameworks (MOFs). We show that the MOF@lipid system can effectively store dye molecules inside the porous scaffold of the MOF while the lipid bilayer prevents their premature release. Efficient uptake of the MOF@lipid nanoparticles by cancer cells makes these nanocarriers promising for drug delivery and diagnostic purposes.