Morphine promotes cancer stem cell properties, contributing to chemoresistance in breast cancer

作者：Dong-ge Niu, Fei Peng, Wei Zhang, Zhong Guan, Hai-Dong Zhao, Jing-Lin Li, Kai-Li Wang, Tingting Li, Yan Zhang, Fei-Meng Zheng, Fan Xu, Qian-Ni Han, Peng Gao, Qing-Ping Wen, Quentin Liu · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.2894 · 被引用次数：79 · 研究领域：Cancer Cells and Metastasis、Cancer, Stress, Anesthesia, and Immune Response

// Dong-Ge Niu 1, 2, 3, * , Fei Peng 1, 2, * , Wei Zhang 1, 2 , Zhong Guan 4 , Hai-Dong Zhao 5 , Jing-Lin Li 1, 2, 3 , Kai-Li Wang 1, 2, 5 , Ting-Ting Li 1, 2 , Yan Zhang 1, 2 , Fei-Meng Zheng 1, 2 , Fan Xu 1, 2, 6 , Qian-Ni Han 1, 2, 3 , Peng Gao 3 , Qing-Ping Wen 3 , Quentin Liu 1, 2 1 Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China 2 Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China 3 Department of Anesthesia, The First Affiliated Hospital, Dalian Medical University, Dalian 116044, China 4 Department of Otorhinolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China 5 Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China 6 Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China * These authors have contributed equally to this work Correspondence to: Quentin Liu, e-mail: liuq9@mail.sysu.edu.cn Qing-Ping Wen, e-mail: wqp.89@163.com Keywords: Morphine, cancer stem cell, chemoresistance, nalmefene, epithelial to mesenchymal transition Received: September 20, 2014      Accepted: December 11, 2014      Published: February 20, 2015 ABSTRACT Morphine is an opioid analgesic drug commonly used for pain relief in cancer patients. Here, we report that m...