Evaluation of Surface Microtopography Engineered by Direct Laser Interference for Bacterial Anti-Biofouling

作者：Jaione Valle, Saioa Burgui, Denise Langheinrich, Carmen Gil, Cristina Solano, Alejandro Toledo‐Arana, Ralf Helbig, Andrés Fabián Lasagni, Íñigo Lasa · 发表于：Macromolecular Bioscience · 年份：2015 · DOI：10.1002/mabi.201500107 · 被引用次数：100 · 研究领域：Bacterial biofilms and quorum sensing、3D Printing in Biomedical Research、Nanofabrication and Lithography Techniques

Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer structures have a profound impact on bacterial adhesion. Thus, line- and pillar-like patterns enhanced S. aureus adhesion, whereas complex lamella microtopography reduced S. aureus adhesion in static and continuous flow culture conditions. Interestingly, lamella-like textured surfaces retained the capacity to inhibit S. aureus adhesion both when the surface is coated with human serum proteins and when the material is implanted subcutaneously in a foreign-body associated infection model.