Chemoselective Pd‐Catalyzed Isocyanide Insertion Reaction of Enaminones by C–H Functionalization: Hydrolysis or Cyclization through 1,3‐Palladium Migration

作者：Zheng‐Yang Gu, Xiang Wang, Jia‐Jia Cao, Shun‐Yi Wang, Shun‐Jun Ji · 发表于：European Journal of Organic Chemistry · 年份：2015 · DOI：10.1002/ejoc.201500458 · 被引用次数：24 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Synthesis and Characterization of Pyrroles

Abstract A chemoselective palladium‐catalyzed isocyanide insertion reaction of enaminones was developed. Amide derivatives were synthesized by this C–H functionalization and subsequent hydrolysis reactions. 4‐Aminoquinoline derivatives were prepared by this C–H functionalization, which includes a 1,3‐palladium migration in the process.