US weight guidelines: is it also important to consider cardiorespiratory fitness?

作者：C D Lee, A S Jackson, Steve N. Blair · 发表于：PubMed · 年份：1998 · 被引用次数：96 · 研究领域：Physical Activity and Health、Cardiovascular and exercise physiology、Cardiovascular Function and Risk Factors

BACKGROUND: The health consequences of weight ranges across low to moderate and high levels of cardiorespiratory fitness are unknown. OBJECTIVE: To evaluate the validity of the 1995 US weight guidelines, while considering cardiorespiratory fitness. METHODS: We followed 21,856 men, aged 30-83 y, who had a complete preventive medical examination, including a maximal treadmill exercise test and body composition assessment. There were 427 deaths (144 cardiovascular disease (CVD); 143 cancer; 140 others) during an average of 8.1 y of follow-up. We used Cox proportional hazards regression to examine the relations among cardiorespiratory fitness, body mass index (BMI, kg/m2), and all-cause and CVD mortality. RESULTS: After adjustment for age, examination year, cigarette smoking and alcohol intake, we observed that men with a BMI of 19.0 to < 25.0 and who were unfit had 2.3 times the risk of all-cause mortality (95% confidence interval (95% CI), 1.59-3.17, P < 0.001) compared with fit men in this BMI group (reference category). Unfit men with a BMI of 25.0 to < 27.8 also had a greater risk of all-cause mortality than fit men in the same BMI category. Fit but overweight men (BMI > or = 27.8) had a similar rate of all-cause mortality as physically fit men of normal weight (BMI 19.0 to < 25.0) and had a lower risk of all-cause mortality than unfit and normal weight men. Fit men of normal weight had the lowest CVD mortality, while unfit and overweight men experienced the highest CVD mort...