Antigenicity of the Major Polypeptides of Hepatitis B Surface Antigen (HBsAg)

作者：J. Wai-Kuo Shih, Peter L. Tan, John L. Gerin · 发表于：The Journal of Immunology · 年份：1978 · DOI：10.4049/jimmunol.120.2.520 · 被引用次数：46 · 研究领域：Hepatitis B Virus Studies、Hepatitis C virus research、Hepatitis Viruses Studies and Epidemiology

The major polypeptides (P-1, P-2, and P-6) of HBsAg were isolated from purified preparations of 22-nm HBsAg particles, iodinated, and analyzed by double-antibody radioimmunoprecipitation assays for the presence of hepatitis B virus (HBV)-specific antigens. Each polypeptide fraction contained both group (a) and subtype (d) specific determinants in common by virtue of their immunoreaction with antiserum to native HBsAg and antisera to the other structural polypeptides. The antigenic and structural similarities of the HBsAg polypeptides establish that they are not each unique gene products of the HBV genome.