Cimetidine reverses tumor growth enhancement of plasmacytoma tumors in mice demonstrating conditioned immunosuppression.

作者：Reginald M. Gorczynski, Martin Alexander Kennedy, Ana Yamaguishi Ciampi · 发表于：The Journal of Immunology · 年份：1985 · DOI：10.4049/jimmunol.134.6.4261 · 被引用次数：83 · 研究领域：Mast cells and histamine、Beetle Biology and Toxicology Studies、Polyamine Metabolism and Applications

Mice were given repeated injections, at 21 day intervals, of cyclophosphamide paired with a novel taste (saccharin) in the drinking water. Subsequent challenge with a syngeneic plasmacytoma tumor led to elevated tumor growth and mortality only in conditioned mice that were reexposed to saccharin. This effect was abolished by conditioned exposure to a histamine type II-receptor antagonist.