Recurrent pregnancy loss: etiology, diagnosis, and therapy.

作者：H. Ford, Danny J. Schust · 发表于：PubMed · 年份：2009 · 被引用次数：553 · 研究领域：Reproductive System and Pregnancy、Ectopic Pregnancy Diagnosis and Management、Gynecological conditions and treatments

Spontaneous pregnancy loss is a surprisingly common occurrence, with approximately 15% of all clinically recognized pregnancies resulting in pregnancy failure. Recurrent pregnancy loss (RPL) has been inconsistently defined. When defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period, it affects approximately 1% to 2% of women. This review highlights the current understanding of the various etiologies implicated in RPL, including factors known to be causative, as well as those implicated as possible causative agents. The appropriate diagnostic evaluation, therapy, and prognosis are also addressed.