Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic

作者：J. Elizabeth Gretz, Eric Peter Kaldjian, Arthur O. Anderson, Stephen Shaw · 发表于：The Journal of Immunology · 年份：1996 · DOI：10.4049/jimmunol.157.2.495 · 被引用次数：201 · 研究领域：T-cell and B-cell Immunology、Monoclonal and Polyclonal Antibodies Research、Receptor Mechanisms and Signaling

The lymph node is the crossroad in which soluble signals and cells carried by lymph meet lymphocytes emigrating from blood. Efficient interactions among these elements depend on the reticular network, which comprises reticular fibers, related extracellular matrix components, and associated fibroblastic reticular cells. This network provides a three-dimensional scaffold for attachment of APCs and pathways for the migration of T cells to these APCs. In addition, the network constitutes a miniature conduit system for bulk flow delivery of soluble molecules to distinct sites in the paracortex, particularly the high endothelial venule. The delivered mediators, such as chemokines, regulate the phenotype of the high endothelial venule, the recruitment of lymphocytes, and the behavior of the recruited lymphocytes. Thus, the reticular network is a multifunctional infrastructure that facilitates encounters of cells with other cells and factors necessary for effective and efficient immune surveillance.