Expression in Escherichia coli of a New Multidrug Efflux Pump, MexXY, from Pseudomonas aeruginosa

作者：Tomoyuki Mine, Yuji Morita, Atsuko Kataoka, Tohru Mizushima, Tomofusa Tsuchiya · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1999 · DOI：10.1128/aac.43.2.415 · 被引用次数：275 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotics Pharmacokinetics and Efficacy、Drug Transport and Resistance Mechanisms

Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli ToIC or P. aeruginosa OprM is necessary for the function of the MexXY system.