Combinatorial approaches to finding subtle signals in DNA sequences.

作者：Pavel A. Pevzner, Sing‐Hoi Sze · 发表于：PubMed · 年份：2000 · 被引用次数：547 · 研究领域：Fractal and DNA sequence analysis、RNA and protein synthesis mechanisms、Machine Learning in Bioinformatics

Signal finding (pattern discovery in unaligned DNA sequences) is a fundamental problem in both computer science and molecular biology with important applications in locating regulatory sites and drug target identification. Despite many studies, this problem is far from being resolved: most signals in DNA sequences are so complicated that we don't yet have good models or reliable algorithms for their recognition. We complement existing statistical and machine learning approaches to this problem by a combinatorial approach that proved to be successful in identifying very subtle signals.