Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain

作者：Hidemi Ishii, HH Salem, C. Elliott Bell, EA Laposata, PW Majerus · 发表于：Blood · 年份：1986 · DOI：10.1182/blood.v67.2.362.362 · 被引用次数：178 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、Venous Thromboembolism Diagnosis and Management、Renin-Angiotensin System Studies

Protein C activation by thrombin is significantly accelerated by the endothelial cell cofactor, thrombomodulin. In this study, we have developed a radioimmunoassay for thrombomodulin and have measured the cofactor content in several human tissues. The assay method detects as little as 2 ng of thrombomodulin. The highest thrombomodulin content was found in lung and placenta, but the antigen was also detected in spleen, pancreas, liver, kidney, skin, heart, and aorta. Unexpectedly, thrombomodulin was absent from brain. Extracts from cerebral cortex, cerebellum, centrum semiovale, midbrain, basal ganglia, pons, and medulla were devoid of thrombomodulin. In contrast, thrombomodulin antigen is present in extracerebral intracranial vessels, including basilar and internal carotid arteries and choroid plexus, as well as in endothelium of the pia-arachnoid.