Dysphagia: epidemiology, risk factors and impact on quality of life – a population‐based study

作者：Guy D. Eslick, Nicholas J. Talley · 发表于：Alimentary Pharmacology & Therapeutics · 年份：2008 · DOI：10.1111/j.1365-2036.2008.03664.x · 被引用次数：303 · 研究领域：Dysphagia Assessment and Management、Gastroesophageal reflux and treatments、Esophageal and GI Pathology

BACKGROUND: Data on the population epidemiology of dysphagia are scarce. Little is known about the prevalence, risk factors and impact on quality of life of dysphagia in the general community. AIM: To determine the magnitude and impact of dysphagia in the general community. METHODS: A random sample of 1000 individuals of Sydney, Australia, were mailed a validated self-report questionnaire to assess dysphagia. Measured were dysphagia symptoms, potential mechanisms, risk factors, psychological disorders, quality of life and demographics. RESULTS: The response rate of included subjects (n = 926) was 73% (n = 672). Dysphagia ever was reported by 16% (n = 110). Multiple logistic regression analysis found that odynophagia was independently associated with gastro-oesophageal reflux disease (GERD) (OR = 3.41, 95% CI: 1.16-10.04). Intermittent dysphagia was independently associated with GERD (OR = 2.96, 95% CI: 1.76-4.98) and anxiety (OR = 1.09, 95% CI: 1.01-1.19). The presence of progressive dysphagia was independently associated with depression (OR = 1.34, 95% CI: 1.07-1.67). Progressive dysphagia was independently associated with reduced 'general health' (OR = 0.95, 95% CI: 0.90-0.99), while intermittent dysphagia was associated with a reduction in the 'role physical' subscale (OR = 0.98, 95% CI: 0.97-0.99). CONCLUSIONS: Dysphagia is remarkably common in the general population. GERD is a risk factor for dysphagia as well as odynophagia. Intermittent dysphagia was associated with an...