A New Intermediate in the Biosynthesis of Squalene

作者：Hans C. Rilling · 发表于：Journal of Biological Chemistry · 年份：1966 · DOI：10.1016/s0021-9258(18)96520-8 · 被引用次数：77 · 研究领域：Plant biochemistry and biosynthesis、Synthetic Organic Chemistry Methods、Phosphorus compounds and reactions

A new intermediate in the biosynthesis of squalene has been isolated and partially characterized. This intermediate, which is the product of the condensation of 2 molecules of farnesyl pyrophosphate, is the pyrophosphate ester of a 30-carbon alcohol whose carbon skeleton is believed to differ from that of squalene by the presence of a cyclopropane ring. It is postulated that squalene is formed directly by the reduction and rearrangement of this compound.