Evolucion de niños post-trasplante hepático luego del primer año de sobrevida

作者：Miriam Cuarterolo, Mirta Ciocca, Susana López, Guillermo Cervio, Luis Rojas, Gustavo Bianco, Ana Speranza, Jorge S. Sasbón, María Teresa García de Dávila, Horacio Questa, José Lipsich, David Bes, C. Montesinos Fernández, Marcelo Dip, Víctor Ayarzabal, Cristina Tau, Elisa Vaiani, Mariana del Pino, Matías Oleastro, Norma Fernández Delgado, Virginia Delfino, Enrique Bravo, Eduviges Norton, Oscar Imventarza · 发表于：Medicina-buenos Aires · 年份：2005 · 被引用次数：7 · 研究领域：Organ Transplantation Techniques and Outcomes、Pediatric Hepatobiliary Diseases and Treatments、Liver Disease and Transplantation

Orthotopic liver transplantation is the only definitive mode of therapy for children with end-stage liver disease. However, it remains challenging because of the necessity to prevent long-term complications. The aim of this study was to analyze the evolution of transplanted patients with more than one year of follow up. Between November 1992 and November 2001, 238 patients underwent 264 liver transplantations. A total of 143 patients with more than one year of follow up were included. The median age of patients ′ SD was 5.41 years ′ 5.26 (r: 0.58-21.7 years). All children received primary immunosuppression with cyclosporine. The indications for liver replacement were: fulminant hepatic failure (n: 50), biliary atresia (n: 38), cirrhosis (n: 37), chronic cholestasis (n: 13) and miscellaneous (n: 5). The indications for liver re-transplantation were: biliary cirrhosis (n: 7), hepatic artery thrombosis (n: 4) and chronic rejection (n: 3). Reduced-size liver allografts were used in 73/157 liver transplants, 14 of them were from living-related donors and 11 were split-livers. Patient and graft survival rates were 93% and 86% respectively. Death risk was statistically higher in retransplanted and reduced-size grafted patients. Growth retardation and low bone density were recovered before the first 3 years post-transplant. The incidence of lymphoproliferative disease was 7.69%. De novo hepatitis B was diagnosed in 7 patients (4.8%). Social risk did not affect the outcome of our popu...