Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus

作者：Rodrigo Sant’Ana Cabral, Maura C. Sartori, Inês Cordeiro, Carmen Lucia Queiroga, Marcos N. Eberlin, João Henrique G. Lago, Paulo Roberto Hrihorowitsch Moreno, Maria Cláudia Marx Young · 发表于：Revista Brasileira de Farmacognosia · 年份：2011 · DOI：10.1590/s0102-695x2011005000219 · 被引用次数：27 · 研究领域：Cholinesterase and Neurodegenerative Diseases、Allelopathy and phytotoxic interactions

Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).