Transitional cell carcinoma in renal transplant recipients: the influence of compound analgesics

作者：Swindle, Falk, Rigby, Petrie, Carmel Mary Hawley, Nicol · 发表于：British Journal of Urology · 年份：1998 · DOI：10.1046/j.1464-410x.1998.00496.x · 被引用次数：42 · 研究领域：Viral-associated cancers and disorders、Renal Transplantation Outcomes and Treatments、Inflammatory mediators and NSAID effects

OBJECTIVES: To determine the incidence of transitional cell carcinoma (TCC) in a renal transplant population and to compare the pattern of neoplasia in patients with analgesic nephropathy (AN) with that in other patients. PATIENTS AND METHODS: Using the Australia and New Zealand Dialysis and Transplant Registry, renal transplant recipients of the Princess Alexandra Hospital with TCC were identified. They were separated into two groups based on their primary disease, i.e. AN (group 1) and other causes of renal failure (group 2). The age at diagnosis of TCC, site, grade, stage of TCC and outcome were then compared between the groups. RESULTS: There were 250 (15%) patients in group 1 and 1424 (85%) in group 2; seven patients in each group were found to have TCC, which thus occurred more frequently in the AN group (2.8%) than in group 2 (0.49%). In group 1, five patients died, four from metastatic disease; of these, the mean time from transplantation to diagnosis of the initial tumour was 4.4 years, with a mean time from diagnosis to death of 9 months. In contrast, there were no deaths from metastatic disease in group 2. In group 1, all patients had upper tract tumours, with five patients also having bladder involvement. The upper tract tumours tended to be of a high stage and grade (grade II-III) and were aggressive. In group 2, all the tumours were confined to the bladder and tended to be of low stage and grade (grade I-II Ta). CONCLUSIONS: Patients undergoing renal transplanta...