Two autopsy cases of severe fever with thrombocytopenia syndrome ( SFTS ) in J apan: A pathognomonic histological feature and unique complication of SFTS

作者：Tsubasa Hiraki, Makoto Yoshimitsu, Tadaki Suzuki, Yuko Goto, Michiyo Higashi, Seiya Yokoyama, Tomohisa Tabuchi, Takahiro Futatsuki, Kentaro Nakamura, Hideki Hasegawa, Masayuki Saijo, Yasuyuki Kakihana, Naomichi Arima, Suguru Yonezawa · 发表于：Pathology International · 年份：2014 · DOI：10.1111/pin.12207 · 被引用次数：95 · 研究领域：Viral Infections and Vectors、Vector-Borne Animal Diseases、Fire effects on ecosystems

We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections.