The effect of teriparatide on serum Dickkopf‐1 levels in postmenopausal women with established osteoporosis

作者：Athanasios D. Anastasilakis, Stergios A. Pοlyzos, Avraam Avramidis, Konstantinos A. Toulis, Αθανάσιος Παπαθεοδώρου, Evangelos Terpos · 发表于：Clinical Endocrinology · 年份：2009 · DOI：10.1111/j.1365-2265.2009.03728.x · 被引用次数：63 · 研究领域：Bone health and osteoporosis research、Wnt/β-catenin signaling in development and cancer、Bone Metabolism and Diseases

OBJECTIVE: Parathyroid hormone increases the differentiation of osteoblast precursors through canonical wingless (Wnt) signalling, resulting in an osteoanabolic effect. We aimed to evaluate serum levels of the Wnt-inhibitor Dickkopf-1 (Dkk-1) in postmenopausal women with established osteoporosis and their changes with teriparatide (TPTD - human recombinant PTH 1-34). DESIGN AND PATIENTS: A total of 31 postmenopausal Caucasian women with established osteoporosis (mean age 66.3 +/- 1.4 years) received daily injections of 20 microg TPTD for 18 months. Follow-up was continued for another 6 months after treatment discontinuation (total duration of treatment 24 months). MEASUREMENTS: Serum samples for total calcium (Ca), intact PTH (iPTH), bone-specific alkaline phosphatase, C-terminal cross-linking telopeptide of type 1 collagen (CTx) and Dkk-1 were obtained at baseline, and at 6, 18 and 24 months after TPTD initiation. Lumbar spine bone mineral density (BMD) was measured before and after 18 months of TPTD treatment. A total of 16 age- and gender-matched healthy controls were also analysed at baseline. RESULTS: Serum Dkk-1 levels at baseline were significantly higher in osteoporotic women compared with that in controls (P < 0.002). Dkk-1 increased significantly during TPTD administration (P < 0.044) and decreased to baseline 6 months after TPTD discontinuation. Dkk-1 change was positively correlated to Ca (r = 0.530, P = 0.004) and negatively correlated to iPTH change (r = -0.398,...