Development and Validation of UV Spectrophotometric Method for Determination of Milnacipran in bulk and Pharmaceutical Dosage Form

作者：Punit B. Parejiya, Pragna Shelat, Rakshit Patel, Bhavesh S. Barot, Arun Kumar Shukla · 发表于：Eurasian Journal of Analytical Chemistry · 年份：2011 · 被引用次数：9 · 研究领域：Analytical Methods in Pharmaceuticals、Antibiotics Pharmacokinetics and Efficacy、Pharmacological Effects and Assays

Milnacipran is an antidepressant drug belonging to the class of serotonin and noradrenaline reuptake inhibitors. A new, rapid, simple and sensitive spectrophotometric method has been developed for the determination of milnacipran in bulk and in pharmaceutical formulations. The linearity was observed in the concentration range of 2-45µg/mL. The method is based on spectrophotometric determinaiton. Absorbance of milnacipran was determined at 220 nm wavelength. The method was validated in terms of accuracy and precision (intra day variations and inter day variation). This method is extended to pharmaceutical preparations. Results of the analysis were validated statistically and by recovery studies. The proposed method was found accurate, reproducible and economical for the routine analysis of milnacipran in bulk and pharmaceutical formulation.