Prediction of Creatinine Clearance from Serum Creatinine

作者：Donald W. Cockcroft, Henry Gault · 发表于：˜The œNephron journals/Nephron journals · 年份：2008 · DOI：10.1159/000180580 · 被引用次数：15440 · 研究领域：Blood Pressure and Hypertension Studies、Health Systems, Economic Evaluations, Quality of Life、Pharmaceutical Practices and Patient Outcomes

A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.