Studies on the relationship between infection with bovine C-type virus, leukemia, and persistent lymphocytosis in cattle.

作者：Jorge F. Ferrer, Donald A. Abt, D. M. Bhatt, Robert R. Marshak · 发表于：PubMed · 年份：1974 · 被引用次数：109 · 研究领域：T-cell and Retrovirus Studies、Animal Disease Management and Epidemiology、Vector-Borne Animal Diseases

Summary Leukemic cows and adult cattle in several herds under long-term surveillance were examined for the presence of antibodies to bovine C-type viruses (BLV) in order to investigate further the possible relationships between infection with this virus, bovine leukemia, and persistent lymphocytosis (PL). This latter condition is considered a preclinical stage of cattle leukemia by some investigators. Fluorescent antibodies reacting specifically with a virion antigen in the cytoplasm of BLV-infected cells were found in 90% of leukemic cows and in 80 to 100% of clinically normal cows with PL in multiple-case herds. The antibody titers of animals with PL were often lower than those of the leukemic cows. Clinically normal cattle with consistently normal lymphocyte counts in the multiple-case herds also showed fluorescent antibodies to BLV; however, in each of these herds the incidence (25 to 76%) and, in most cases, the titers of antibodies found in the nonlymphocytotic animal groups were lower than those of the corresponding PL groups. The antibody was also present in one-third of the cattle in a single-case herd in which the PL rate was not significant. In contrast, antibody was found in only 4 out of 214 animals from leukemia-free herds. In two multiple-case herds in which pedigree data are available, it was observed that animals from high-risk families had fluorescent antibodies to BLV at a significantly higher frequency, and often at higher titers, than animals from minimal...