PRESYNAPTIC γ-AMINOBUTYRIC ACID RESPONSES IN THE OLFACTORY CORTEX

作者：Hilary G. Pickles · 发表于：British Journal of Pharmacology · 年份：1979 · DOI：10.1111/j.1476-5381.1979.tb07822.x · 被引用次数：41 · 研究领域：Olfactory and Sensory Function Studies、Neuroscience and Neuropharmacology Research、Biochemical Analysis and Sensing Techniques

1. Potential changes were recorded from the lateral olfactory tract in slices of rat olfactory cortex in vitro at room temperature. 2. Superfused gamma-aminobutyric acid (GABA) usually produced dose-related depolarization of the lateral olfactory tract. Muscimol and 3-aminopropanesulphonic acid appeared more potent depolarizing agents than GABA, and glycine and taurine appeared less potent. Carbachol and glutamate were virtually ineffective. 3. The GABA responses were at least partially Cl- dependent. 4. (+)-Bicuculline and higher concentrations of strychnine antagonized the GABA but not the glycine-induced depolarizations. Paradoxically, responses to high doses of GABA were sometimes potentiated by both bicuculline and strychnine. 5. It is suggested that GABA receptors could occur as widely on nerve terminals as they do postsynaptically in the CNS, where GABA could be involved in the modulation of transmitter output.