Adaptive Immune Response of Vγ2Vδ2 + T Cells During Mycobacterial Infections

作者：Yun Shen, D. J. Zhou, Liyou Qiu, Xioamin Lai, Meredith A. Simon, Ling Shen, Zhongchen Kou, Qifan Wang, Liming Jiang, Jim Estep, Robert E. Hunt, Michelle Clagett, Prabhat K. Sehgal, Yunyaun Li, Xuejun Zeng, Craig T. Morita, Michael B. Brenner, Norman L. Letvin, Zheng W. Chen · 发表于：Science · 年份：2002 · DOI：10.1126/science.1068819 · 被引用次数：394 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、Immune Response and Inflammation

To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2+ T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections.