Signal transduction in bacterial chemotaxis.

作者：Jeffry B. Stock, Michael Gordon Surette, William R. McCleary, Ann Marie Stock · 发表于：Journal of Biological Chemistry · 年份：1992 · DOI：10.1016/s0021-9258(19)88615-5 · 被引用次数：129 · 研究领域：Bacterial Genetics and Biotechnology、Protein Structure and Dynamics、RNA and protein synthesis mechanisms

Motile bacteria respond to environmental cues tomove to more favorable locations. The components of the chemotaxis signal transduction systems that mediate these responses are highly conserved among prokaryotes including both eubacterial and archael species. The best-studied system is that found in Escherichia coli. Attractant and repellant chemicals are sensed through their interactions with transmembrane chemoreceptor proteins that are localized in multimeric assemblies at one or both cell poles together with a histidine protein kinase, CheA, an SH3-like adaptor protein, CheW, and a phosphoprotein phosphatase, CheZ. These multimeric protein assemblies act to control the level of phosphorylation of a response regulator, CheY, which dictates flagellar motion. Bacterial chemotaxis is one of the mostunderstood signal transduction systems, and many biochemical and structural details of this system have been elucidated. This is an exciting field of studybecause thedepthof knowledgenowallows thedetailedmolecular mechanisms of transmembrane signaling and signal processing to be investigated. BioEssays 28:9–22, 2006. 2005 Wiley Periodicals, Inc.