Isotype profiles of anti-influenza antibodies in mice bearing the xid defect

作者：Marcella Reale, C Bona, Jerome L. Schulman · 发表于：Journal of Virology · 年份：1985 · DOI：10.1128/jvi.53.2.425-429.1985 · 被引用次数：14 · 研究领域：Influenza Virus Research Studies、interferon and immune responses、Immune Response and Inflammation

The humoral response to influenza A/PR8 virus was examined in the CBA/N and C3J.xid strains of mice, both of which bear an X-linked genetic defect (xid), and in strains lacking this defect. Hemagglutination-inhibiting antibody titers and measurement of virus-specific antibodies by solid-phase radioimmunoassay indicated that the xid defect does not impair the production of an adequate anti-influenza antibody response. However, investigation of the isotypes of PR8 virus-specific antibodies disclosed a relative decrease in the levels of IgG3 and IgG1 in the xid-bearing strains. This was observed after both intraperitoneal immunization and aerosol infection. The isotype differences were not reflected in the susceptibility of these strains to influenza virus infection.