Intensive chemoradiation followed by esophagectomy for squamous cell and adenocarcinoma of the esophagus.

作者：Arlene A. Forastiere, Richard F. Heitmiller, Ding Jen Lee, MARIANNA L. ZAHURAK, Ross Allen Abrams, Lawrence Richard Kleinberg, Stanley P. Watkins, Charles J. Yeo, Keith D. Lillemoe, James V. Sitzmann, William Howard Sharfman · 发表于：PubMed · 年份：1997 · 被引用次数：78 · 研究领域：Esophageal Cancer Research and Treatment、Colorectal and Anal Carcinomas、Head and Neck Cancer Studies

PURPOSE: To determine the pathologic complete response rate, toxicity, and survival of patients with resectable squamous cell or adenocarcinoma of the esophagus treated with a 30-day preoperative chemoradiation regimen and surgical resection. PATIENTS AND METHODS: Fifty patients (16 squamous, 33 adeno, one undifferentiated) who had carcinoma of the esophagus (limited to the primary tumor and regional or celiac nodes) were treated with cisplatin 26 mg/m2/day continuous infusion days 1 through 5 and 26 through 30, 5-fluorouracil (5-FU) 300 mg/m2/day continuous infusion days 1 through 30, and radiation 44 Gy, 2 Gy/fx in 22 daily fractions, days 1 through 30, followed by esophagectomy. RESULTS: Forty-seven patients underwent esophagectomy (94% operability rate), and 45 had total gross removal of disease and negative margins of resection (90% resectability rate). Nineteen patients (40%) had a pathologic complete response (CR). Forty (80%) received 100% of the planned cisplatin dose, 29 (58%) received 100% of the planned 5-FU dose, and 40 (80%) received > or = 80% of the planned 5-FU dose. Forty-five (90%) received the planned 44-Gy radiation dose. Grade 3 or 4 neutropenia occurred in 60% of patients. The incidence of febrile neutropenia was 34%. There was one septic death during chemoradiation and no operative deaths. Weight loss requiring nutritional support occurred in 50% of patients, secondary to anorexia, dysphagia, and/or esophagitis. The survival of all registered patients ...