The Regulation of Arginine Biosynthesis in Saccharomyces cerevisiae. The Specificity of argR- Mutations and the General Control of Amino-Acid Biosynthesis

作者：Jacqueline Delforge, Francine Messenguy, Jean‐Marie Wiame · 发表于：European Journal of Biochemistry · 年份：1975 · DOI：10.1111/j.1432-1033.1975.tb02295.x · 被引用次数：143 · 研究领域：Polyamine Metabolism and Applications、Fungal and yeast genetics research、Fermentation and Sensory Analysis

The regulation of arginine biosynthetic enzymes in yeast is subjected to a double control. One level of arginine enzyme synthesis is under the control of an apo-repressor, called ARGR. ARGR molecules control specifically the arginine pathway. A second level of control of arginine biosynthesis has been disclosed. It also controls tryptophan, histidine, lysine, isoleucine-valine and probably many more biosyntheses. The general mechanism is turned on in leaky mutants in any of the amino acid pathways mentioned above.