Free radical metabolites of L-cysteine oxidation.

作者：Laura S. Harman, Carolyn Mottley, Ronald Paul Mason · 发表于：Journal of Biological Chemistry · 年份：1984 · DOI：10.1016/s0021-9258(18)91057-4 · 被引用次数：244 · 研究领域：Glutathione Transferases and Polymorphisms、Sulfur Compounds in Biology、Free Radicals and Antioxidants

The oxidation of L-cysteine by horseradish peroxidase in the presence of oxygen forms a thiyl free radical as demonstrated with the spin-trapping ESR technique. Reactions of this thiyl free radical result in oxygen consumption, which is inhibited by the spin trap 5,5'-dimethyl-1-pyrroline-N-oxide. Cysteine sulfinic acid, a cysteine metabolite, is a poorer substrate for horseradish peroxidase than cysteine and is oxidized to form both sulfur-centered and carbon-centered free radicals.