Mitogenic Effect of Bacterial Peptidoglycans Possessing Adjuvant Activity

作者：C. Damais, Cleiton Chiamonti Bona, LOUIS A. CHEDID, Jacqueline Fleck, C Nauciel, J P Martin · 发表于：The Journal of Immunology · 年份：1975 · DOI：10.4049/jimmunol.115.1.268 · 被引用次数：84 · 研究领域：Bacterial Genetics and Biotechnology、Cancer therapeutics and mechanisms、Antibiotic Resistance in Bacteria

Two purified peptides extracted from E. coli or B. megaterium strongly stimulated the spleen lymphocytes of rabbits and of normal or nude mice. Both preparations can substitute for Mycobacteria in Freund's complete adjuvant. The peptidoglycan extracted from M. lysodeikticus by a similar procedure which lacks adjuvant activity, did not induce blast transformation. However, the monomere of the E. coli peptidoglycan was devoid of mitogenicity although it has also a marked adjuvant activity.