Diffusion and convection in normal and neoplastic tissues.

作者：Edward A. Swabb, James Cheng-Chung Wei, Pietro M. Gullino · 发表于：PubMed · 年份：1974 · 被引用次数：403 · 研究领域：MRI in cancer diagnosis、Liver Disease Diagnosis and Treatment、Diet and metabolism studies

Summary The hydraulic conductivity of s.c. and hepatocarcinoma tissue was determined by in vivo and in vitro experiments. A single parameter was developed to calculate the ratio of diffusive to convective flux of solutes in the extravascular space. Tissue glycosaminoglycan content and solute molecular weight are the two most important parameters which may determine whether the extravascular transport of solutes occurs predominantly by diffusion or by convection. The analysis has implications for transport of metabolic nutrients and wastes, drugs, hormones, plasma proteins, and viruses in the extravascular space.