The effect of ionomycin on calcium fluxes in sarcoplasmic reticulum vesicles and liposomes.

作者：Troy Beeler, István Jóna, A. Martonosi · 发表于：Journal of Biological Chemistry · 年份：1979 · DOI：10.1016/s0021-9258(18)50350-1 · 被引用次数：62 · 研究领域：bioluminescence and chemiluminescence research、Nicotinic Acetylcholine Receptors Study、Ion channel regulation and function

Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M. The effect is due to an increase in the Ca2+ permeability of the membrane which is also observed on liposomes. The inhibition of Ca2+ uptake is accompanied by an increase in the Ca2+-sensitive ATPase activity of sarcoplasmic reticulum vesicles.