SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes

作者：Theodore K. Malmstrom, Douglas K. Miller, Eleanor Marie Simonsick, Luigi Ferrucci, John Edward Morley · 发表于：Journal of Cachexia Sarcopenia and Muscle · 年份：2015 · DOI：10.1002/jcsm.12048 · 被引用次数：1179 · 研究领域：Nutrition and Health in Aging、Frailty in Older Adults、Balance, Gait, and Falls Prevention

BACKGROUND: A brief, inexpensive screening test for sarcopenia would be helpful for clinicians and their patients. To screen for persons with sarcopenia, we developed a simple five-item questionnaire (SARC-F) based on cardinal features or consequences of sarcopenia. METHODS: We investigated the utility of SARC-F in the African American Health (AAH) study, Baltimore Longitudinal Study of Aging (BLSA), and National Health and Nutrition Examination Survey (NHANES). Internal consistency reliability for SARC-F was determined using Cronbach's alpha. We evaluated SARC-F factorial validity using principal components analysis and criterion validity by examining its association with exam-based indicators of sarcopenia. Construct validity was examined using cross-sectional and longitudinal differences among those with high (≥4) vs. low (<4) SARC-F scores for mortality and health outcomes. RESULTS: SARC-F exhibited good internal consistency reliability and factorial, criterion, and construct validity. AAH participants with SARC-F scores ≥ 4 had more Instrumental Activity of Daily Living (IADL) deficits, slower chair stand times, lower grip strength, lower short physical performance battery scores, and a higher likelihood of recent hospitalization and of having a gait speed of <0.8 m/s. SARC-F scores ≥ 4 in AAH also were associated with 6 year IADL deficits, slower chair stand times, lower short physical performance battery scores, having a gait speed of <0.8 m/s, being hospitalized recen...