Delivery Strategies for Antisense Oligonucleotide Therapeutics

年份：2017 · DOI：10.1201/9781315150901 · 被引用次数：85 · 研究领域：DNA and Nucleic Acid Chemistry、RNA and protein synthesis mechanisms

PrefaceOverview of Antisense Oligonucleotide Therapeutics and DeliveryDisrupting the Flow of Genetic Information with Antisense Oligodeoxynucleotides: Research and Therapeutic Applications, D. Kregenow, M.Z. Ratajczak, and A. GewirtzCellular Delivery of Ribozymes, D.A. Elkins and J.J. RossiImproved Structural Design and Cellular Uptake of GT-Rich Triplex-Forming Oligonucleotides, N. Choudhary, J.S. Bishop, K. Jayaraman, and J.K. Guy-CaffeyPharmacokinetic and Distribution StudiesPharmacokinetics and Delivery of Oligonucleotides to the Brain, L. Neckers, D.A. Geselowitz, and C. ChavanyIn Vivo Pharmacokinetics of Oligonucleotides Following Administration by Different Routes, V.V. Vlassov, L.A. Yakubov, V. Karamyshev, L. Pautova, E. Rykova, and M. NechaevaImproving Biological Stability of OligonucleotidesNuclease-Resistant Nucleic Acid Therapeutics, E. WickstromSelf-Stabilized Oligonucleotides as Novel Antisense Agents, S. Agrawal, J. Temsamani, and J. TangCircular Oligonucleotides as Potential Modulators of Gene Expression, E.T. KoolPeptide Nucleic Acids as Antisense Therapeutic Agents, J.C. Hanvey and L.E. BabissStabilized RNA Analogues for Antisense and Ribozyme Applications, H. Arup, O. Heindenreich, F. EcksteinImproving Membrane Transport and Targeted Delivery of Antisense OligonucleotidesUptake and Localization of Phosphodeister and Chimeric Oligodeoxynucleotides in Normal and Leukaemic Primary Cells, A. KreigOligonucleotide Transport across Membranes and into Cells: Effect...