Effect of 20( S )‐ginsenoside Rg3 on streptozotocin‐induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid‐resolution liquid chromatography/mass spectrometry

作者：Jun Niu, Zifeng Pi, Hao Yue, Hongmei Yang, Yang Wang, Qing Yu, Shuying Liu · 发表于：Rapid Communications in Mass Spectrometry · 年份：2012 · DOI：10.1002/rcm.6392 · 被引用次数：29 · 研究领域：Ginseng Biological Effects and Applications、Metabolomics and Mass Spectrometry Studies、Traditional Chinese Medicine Analysis

RATIONALE: 20(S)-ginsenoside Rg3 is an active component of Panax ginseng. It is known that 20(S)-ginsenoside Rg3 has a protective effect against hyperglycemia, obesity and diabetes in vivo, but the precise mechanisms of these actions have not yet been entirely elucidated. METHODS: A urinary metabonomics method based on rapid-resolution liquid chromatography/mass spectrometry (RRLC/MS) was developed to investigate the effect of 20(S)-ginsenoside Rg3 on type 2 diabetic rats. RESULTS: With multivariate statistical analysis, a clear separation between type 2 diabetic rats and those treated with 20(S)-ginsenoside Rg3 was achieved. Six potential biomarkers were found and identified. CONCLUSIONS: This work shows that the mechanism of the effect of 20(S)-ginsenoside Rg3 on type 2 diabetes may be involved with the regulation of nucleic acid metabolism, energy metabolism and gut flora metabolism.